Method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione
AssigneeSumitomo Dainippon Pharma Co., Ltd.
InventorsToshikazu Yagi, Satoshi Suzuki, Hiroto Tatamidani, Kazuki Hashimoto
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Abstract
The invention addresses the problem of providing a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione that is suited to industrial production. The invention provides a method for producing 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by reacting 3-bromo-3-buten-2-one and 2-hydroxy-1,4-naphthoquinone in the presence of a solvent, then obtaining crystals of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione by adding an alcohol-based solvent and/or water to the reaction system, and treating the crystals by using a specific adsorbent in the presence of a solvent.
Claims36
A production method of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione comprising the following steps (c) and (d):
- (c) reacting 3-bromo-3-buten-2-one, 2-hydroxy-1,4-naphthoquinone, and a base in the presence of a non-alcohol, non-ketone-based solvent A, and adding an alcohol-based solvent B and/or water to obtain a crystal of 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione;
- and
- (d) dissolving 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione obtained in the step (c) in a non-alcohol-based solvent C, followed by adding an adsorbent to purify the 2-acetyl-4H,9H-naphtho[2,3-b]furan-4,9-dione.
Dependencies are inferred from the claim text.