TRPA1 and TRPV4 inhibitors and methods of using the same for organ-specific inflammation and itch
AssigneeDuke University
InventorsWolfgang Liedtke, Farshid Guilak
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Abstract
Provided are methods of treating and/or preventing dermatological disorders. Provided are methods of reducing skin inflammation, reducing pain, and/or reducing itch in a subject in need thereof. The methods may include administering to the subject an effective amount of a TRPA1 and/or TRPV4 inhibitor. Further provided are compositions including a TRPA1 and/or TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent that is suitable for topical application.
Claims9
A composition comprising a TRPA1 and TRPV4 inhibitor compound in combination with a carrier, vehicle, or diluent, wherein the TRPA1 and TRPV4 inhibitor comprises a compound selected from the following:
A topical formulation comprising a TRPA1 and TRPV4 inhibitor, wherein the TRPA1 and TRPV4 inhibitor comprises a compound selected from the following:
A compound selected from the following:
Dependencies are inferred from the claim text.