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US 10,329,264 B2Granted
Process for the preparation of isocarboxazid
AssigneeLundbeck Pharmaceuticals Italy S.P.A.
InventorsCarla De Faveri, Florian Anton Martin Huber, Nicola Antolini
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Abstract
This invention relates to a novel chemical process for the synthesis of N′-benzyl-5-methylisoxazole-3-carbohydrazide (Isocarboxazid) which comprises reacting 5-methyl-3-isoxazole carboxylic acid ester with benzylhydrazine or a salt thereof in an aprotic organic solvent and in the presence of an organic base.
Claims15
A process for preparing N′-benzyl-5-methylisoxazole-3-carbohydrazide (Isocarboxazid), which comprises
- a) reacting 5-methyl-3-isoxazole carboxylic acid ester (II),
- wherein R is a C1-4 alkyl,
- with benzylhydrazine or a salt thereof (III)
- in an aprotic organic solvent and in the presence of an organic base.
1 more element
Dependencies are inferred from the claim text.