CGAS in systemic lupus erythematosus (SLE)

A compound of Formula (II) or a prodrug thereof,

• wherein
• R1 is —Cl, —OH, —NH2, or —NO2;
• R6 is
• and
• n is 3 or 4.

A compound of Formula (I) or a prodrug thereof,

• wherein
• R1 is —H, —Cl, —OH, —NH2 or —NO2;
• R2 is —H or —OCH3;
• R3 and R4 are independently —H or —CH3;
• R5 and R6 are independently —H, —CH3, —CH2CH2SH,
• and
• n is 2 or 3.

A method for the treatment of an autoimmune disease or a monogenic disorder, the method comprising administering an effective amount of a compound of Formula (III) or a prodrug thereof,

• wherein
• R1 is —H, halogen, —OH, —OCH3, —NH2, —NMe2, —N(H)C(O)R7 or —NO2,
• wherein R7 is —OCH3, —OCH2CH3, —OCH2CH2CH3, —OCH2CH2CH2CH3, —CH3, —CH2CH3, —CH2 CH2CH3, —CH2CH2CH2CH3, —CH2CH2CH2CH2CH3, —CH2CH2CH2CH2CH2CH3, —CF3, —CH2CF3 or
• ring X is absent or
• wherein R2 is —H, halogen, —NMe2, —OCH3 or —OCH2CH3;
• X is —H, —NH2,
• wherein
• R3 is —H or —CH3;
• R4 is —H or —CH3;
• R5 and R6 are independently —H, —CH3, —CH2CH3, —CH2CH2SH, —CH2CH2OH,
• RY is —NO2, —C(O)OCH2CH3 or —N(H)SO2Me;
• and
• n is 2 or 3;
• to a patient in need thereof, wherein the autoimmune disease is selected from the group consisting of systemic lupus erythematosus, inflammatory bowel disease, diabetes mellitus, Sjögren's syndrome, scleroderma, and polymyositis, and wherein the monogenic disorder is Aicardi-Goutiéres's Syndrome.