Compositions and methods for treating tuberculosis

A method of treating a mycobacterial infection in a subject, comprising administering to the subject a compound having a structure of Formula (I) or a pharmaceutically acceptable salt thereof:

• wherein, independently for each occurrence,
• R1 is unsubstituted lower alkyl,
• R2 is unsubstituted lower alkyl,
• R4 is selected from hydrogen, substituted or unsubstituted acyl, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted alkylamino, amino, substituted or unsubstituted dialkylamino, sulfonamido, —C(O)OR5, —C(O)R7, —C(O)NR5R6, —C(O)NHS(O2)R7 and —S(O2)R7;
• R5 is hydrogen, substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, or substituted or unsubstituted heterocyclyl;
• R6 is hydrogen, hydroxyl, substituted or unsubstituted alkyl or substituted or unsubstituted cycloalkyl;
• or
• R5 and R6 together with the nitrogen to which they are attached form a substituted or unsubstituted heterocyclyl;
• R7 is substituted or unsubstituted alkyl, substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl or substituted or unsubstituted heteroaryl;
• Cy1 is selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl;
• and
• Cy2 is selected from substituted or unsubstituted cycloalkyl, substituted or unsubstituted heterocyclyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl.