Process for the synthesis of 2-(2,5-dimethyl-1H-pyrrol-1-yl)-1,3-propanediol and its substituted derivatives

Process for the preparation of a compound of formula (I)

• wherein R1, R2, R3, R4 are independently selected from the group consisting of:
• hydrogen, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C2-C30 linear or branched alkyl, aryl, alkyl-aryl, C2-C30 linear or branched alkenyl-aryl, C2-C30-alkynyl aryl, heterocycle, said process comprising the following steps:
• a) reacting a compound of formula (II)
• wherein R1, R4 are independently selected from the group consisting of:
• hydrogen, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C2-C30 linear or branched alkyl, aryl, alkyl-aryl, C2-C30 linear or branched alkenyl-aryl, C2-C30-alkynyl aryl, heterocycle,
• and R5, R6 are independently selected from the group consisting of:
• hydrogen, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C2-C30 linear or branched alkyl, aryl, alkyl-aryl, C2-C30 linear or branched alkenyl-aryl, C2-C30-alkynyl aryl, heterocycle, with a compound of formula (III)
• without solvents and/or organic diluents and without acids, with formation of an intermediate compound of formula (IV)
• wherein R1, R2, R3, R4 are independently selected from the group consisting of:
• hydrogen, C1-C30 alkyl, C2-C30 alkenyl, C2-C30 alkynyl, C2-C30 linear or branched alkyl, aryl, alkyl-aryl, C2-C30 linear or branched alkenyl-aryl, C2-C30-alkynyl aryl, heterocycle;
• b) converting the compound of formula (IV) to the compound of formula (I) by heating the reaction mixture to a temperature from 100 to 200° C. for a time comprised from 1 to 500 minutes,
• or by adding a carbon allotrope or its derivatives.