Biphenyl derivative and uses thereof
AssigneeXi'an Libang Pharmaceutical Co., Ltd
InventorsRutao Wang, Tao Chen, Long An, Yi Zhao, Weijiao Wang, Shupan Guo, Sa Xiao, Jinghua Pang, Huijing Hu
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Abstract
The present invention relates to a biphenyl derivative and use thereof, and the biphenyl derivative has a structure represented by the formula (I) as defined in the specification. The use refers the use of the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof, or a pharmaceutical composition comprising the biphenyl derivative or a pharmaceutically acceptable salt or solvate thereof in the preparation of a medicament for the treatment and/or prevention of ischemic stroke.
Claims12
A biphenyl derivative represented by formula I or a pharmaceutically acceptable salt or solvate thereof,
- wherein R1R3, R4, and R6 in the biphenyl derivative are each independently n-propyl or isopropyl;
- R2 is selected from the group consisting of optionally substituted hydroxyl, optionally substituted carboxyl, optionally substituted acyl, optionally substituted ester, and halogen;
- R5 is selected from the group consisting of optionally substituted hydroxyl, optionally substituted carboxyl, optionally substituted acyl, optionally substituted ester, and halogen;
- with the proviso that when R2 and R5 are both hydroxyl, R1, R3, R4, and R6 are not simultaneously isopropyl;
- wherein the biphenyl derivative has a structure selected from a group consisting of:
Dependencies are inferred from the claim text.