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US 10,329,236 B2Granted
Procedure for the preparation of 4-phenyl butyrate and uses thereof
AssigneeHorizon Therapeutics, LLC
InventorsHuai-Chueh Chang, Steven S. Pfeiffer, Vasilios H. Iskos, Maki Uragami, Steven Weissman, Andrew Thompson
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Abstract
Provided is a process for preparing 4-phenyl-1-butyric acid, comprising: reacting 4-phenyl-1-butanol with sodium chlorite, a nitroxyl radical catalyst and sodium hypochlorite in an organic solvent and a phosphate buffer; and quenching the reaction with sodium sulfite to produce 4-phenyl-1-butyric. Also provided is 4-phenyl-1-butyric acid prepared by such a process.
Claims6
A pharmaceutical composition consisting of glycerol triphenylbutyrate having the structure:
- wherein the glycerol triphenylbutyrate has a purity that is greater than about 99% by high performance liquid chromatography (HPLC) analysis,
- less than 0.1% of any single individual impurity w/w as measured by area percentage of HPLC;
- and
- less than 0.04% 3-benzoyl propionic acid w/w as measured by area percentage of HPLC.
1 more element
Dependencies are inferred from the claim text.