Retrievability for implantable medical devices
AssigneeCardiac Pacemakers, Inc.
InventorsJoseph Thomas Delanely, Jr., Michael J. Kane, Benjamin J. Haasl, Danielle Frankson
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Abstract
An implantable medical device (IMD) may include an outer housing having a titanium outer surface, the titanium outer surface including a plurality of titanium atoms. A tissue growth-inhibiting layer may extend over the titanium outer surface. In some cases, the tissue growth-inhibiting layer may include a plurality of polyethylene glycol molecules, at least some of the plurality of polyethylene glycol molecules covalently bonded via an ether bond to one of the plurality of titanium atoms.
Claims19
An implantable medical device (IMD), comprising:
- an outer housing having a titanium outer surface;
- the titanium outer surface comprising a plurality of titanium atoms;
- a tissue growth-inhibiting layer extending over the titanium outer surface;
- the tissue growth-inhibiting layer comprising a plurality of polyethylene glycol molecules, at least some of the plurality of polyethylene glycol molecules covalently bonded via an ether bond to one of the plurality of titanium atoms;
- and
- wherein the tissue growth-inhibiting layer is formed by hydroxylating at least some of the plurality of titanium atoms and covalently bonding a plurality of hydroxyl-terminated polyethylene glycol molecules to the hydroxylated titanium atoms with a concomitant loss of water molecules.
A leadless cardiac pacemaker (LCP) configured for removal after having been chronically implanted, the LCP comprising:
- an outer housing extending from a proximal end to a distal end;
- a fixation element extending distally from the distal end;
- a retrieval feature extending proximally from the proximal end;
- at least a portion of the LCP including a titanium outer surface;
- and
- a tissue growth-inhibiting layer extending over at least a portion of the titanium outer surface, the tissue growth-inhibiting layer comprising a plurality of polyethylene glycol molecules each covalently bonded to titanium atoms within the titanium outer surface.
A method of instilling tissue growth resistance to at least a portion of an implantable medical device (IMD), the IMD having a titanium outer surface, the method comprising:
- subjecting the titanium outer surface to a plasma treatment to provide hydroxyl groups on the titanium outer surface, the hydroxyl groups covalently bonded to titanium atoms within the titanium outer surface;
- contacting the hydroxyl groups on the titanium outer surface with hydroxyl-terminated polyethylene glycol molecules;
- and
- wherein the hydroxyl-terminated polyethylene glycol molecules covalently bond with the hydroxyl groups on the titanium outer surface with a concomitant loss of water molecules.
Dependencies are inferred from the claim text.