Apparatus and method for calibrating acoustic desynchronizing neurostimulation

An apparatus for stimulating neurons having a pathologically synchronous and oscillatory neural activity, comprising:

• a stimulation unit configured to apply pulsed sounds to a patient, wherein the sounds stimulate neurons of the patient;
• a measuring unit configured to record measured signals that reproduce a neural activity of the stimulated neurons;
• and
• a control unit configured to control the stimulation unit and configured to analyze the measured signals, wherein the control unit is further configured to:
• control the stimulation unit to apply a first pulse train with a varied frequency,
• select at least one first frequency range or at least one first frequency in or at which a phase synchronization is present between the pulse train and the neural activity with reference to the measured signals recorded in response to the application of the first pulse train,
• control the stimulation unit to apply two phase-shifted second pulse trains, wherein respective frequencies of the two second pulse trains are varied relative to each other and a start value is selected for the frequency of the second pulse trains based on the at least one first frequency range or on the at least one first frequency, and
• select at least one second frequency range or at least one second frequency to minimize an amplitude of the neural activity with reference to the measured signals recorded in response to the application of the second pulse trains.