Systems and methods for ambulatory generation of nitric oxide

A wearable nitric oxide generation system comprising:

• a housing configured to be wearable;
• a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers;
• one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;
• a controller configured to regulate the amount of nitric oxide generated in the reactant gas;
• a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers;
• and
• a connector to deliver the product gas to a patient delivery device;
• wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit;
• and
• wherein the resonant frequency is automatically determined at a power-up of the system.

A wearable nitric oxide generation system comprising:

• a housing configured to be wearable;
• a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers;
• one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;
• a controller configured to regulate the amount of nitric oxide generated in the reactant gas;
• a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers;
• and
• a connector to deliver the product gas to a patient delivery device;
• wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit;
• and
• wherein the resonant frequency is automatically determined at the beginning of each patient treatment.

A wearable nitric oxide generation system comprising:

• a housing configured to be wearable;
• a reactant gas flow path located in the housing, the reactant gas flow path configured to provide release of a pressurized reactant gas at specific flow rates to one or more plasma chambers;
• one or more electrodes located in the one or more plasma chambers configured to generate a product gas containing nitric oxide using a flow of the reactant gas through the one or more plasma chambers;
• a controller configured to regulate the amount of nitric oxide generated in the reactant gas;
• a disposable cartridge including one or more scavenger paths configured to remove NO2 from the product gas generated by the one or more plasma chambers;
• and
• a connector to deliver the product gas to a patient delivery device;
• wherein the controller measures a resonant frequency of a high voltage circuit and controls a frequency and a duty cycle of an AC waveform to maximize excitation of the high voltage circuit;
• and
• wherein the resonant frequency is stored in memory between uses so that a resonance search is not required at power-up of the system.