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US 10,328,213 B2Granted
Cell injection needle
AssigneeMuffin Incorporated
InventorsRichard B. Sisken, Ryan Pruchnic, Frank J. Fischer, Jr., Steven Charlebois
Life of this patent
Estimating the term…
Abstract
Methods and apparatus are provided for treating tissue with apparatus that includes an priming portion for initiating a healing response in the tissue to be treated, and which delivers a bioactive agent during or after preparing tissue adjacent the apparatus, as by generating or aiding a healing, regeneration or repair response in the tissue. The priming portion may comprise an abrasive surface, fluid ejection ports, and/or stimulation by electrical, thermal, or light energy.
Claims15
A cell delivery system, comprising:
- an elongated needle body comprising a sheath having a longitudinal axis, an inner diameter defining a cavity adapted to hold a plurality of cells and a distal end surface, and a central portion partially within the sheath and along the longitudinal axis, the central portion including an end region, the sheath and central portion being movable with respect to each other along or around the longitudinal axis, the sheath terminating in a distal tip adapted for tissue penetration, said sheath and central portion capable of transition from a first configuration for insertion into tissue, in which the end region is positioned within the distal end surface of the sheath to seal the cavity to provide a continuous smooth transition between an external surface of the central portion and an exterior surface of the sheath such that the external surface of the central portion has a flush contact area with the distal surface of the sheath, to a second configuration in which the end region is configured to extend distally from the sheath to open the cavity for delivery of cells when a portion of said body is adjacent a tissue location where therapy is desired, and wherein from the second configuration the central portion is configured to move into the sheath until the end region is positioned within the distal end surface of the sheath, wherein the sheath and central portion are capable of relative rotational movement around the longitudinal axis during transition from the first configuration to the second configuration.
A cell delivery system, comprising:
- an elongated body comprising an outer sheath portion defining a cell-carrying portion to hold a plurality of cells, the outer sheath portion terminating at a tissue-penetrating tip arranged to penetrate tissue as the tissue-penetrating tip is forced into bodily tissue, the body further including a central portion extending through the outer sheath portion, the central portion having a distal end region adapted to move along or around a longitudinal axis of said outer sheath portion, the body further having a priming portion positionable adjacent to said tissue-penetrating tip during a first configuration;
- said outer sheath portion and central portion capable of transition from the first configuration for insertion into tissue, in which the distal end region is fully positioned within the tissue-penetrating distal tip of the outer sheath to seal the cell-carrying portion such that the distal end region of the central portion has a flush contact area with the tissue-penetrating tip of the outer sheath portion in the insertion configuration to a second configuration in which the distal end region is configured to extend distally from the outer sheath to open the cell-carrying portion for delivery of cells;
- wherein sail outer sheath portion and said central portion are capable of relative rotational movement around the longitudinal axis during transition from the first configuration to the second configuration.
Dependencies are inferred from the claim text.