Model-based infusion site monitor

A device, comprising:

• a vascular access device (VAD) configured to deliver a medication to an infusion site region of a patient;
• a user interface configured to receive input information, wherein the input information includes patient information;
• a sensor that measures a plurality of fluid state parameters of a fluid delivery channel through which the medication is delivered by the VAD to the infusion site region of a patient, wherein the fluid state parameters comprise pressure and resistance;
• an output device;
• and
• a processor that (i) creates a model of a state of the infusion site region, comprising fluid state parameters of an interstitial tissue at the infusion site region, based on the fluid state parameters and the input information, wherein the model comprises a determination of a hydrostatic pressure component of a fluid flow and an osmotic gradient component of the fluid flow, the osmotic gradient component being indicative of a difference in a protein concentration across a membrane of the fluid delivery channel, and (ii) provides a communication to the output device if the fluid state parameters at the infusion site region are not within the model of a state of the infusion site region.