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US 10,328,162 B1Granted
CEST systems exhibiting a concentration independent responsiveness
AssigneeBracco Imaging S.P.A.
InventorsSilvio Aime, Daniela Delli Castelli, Franco Fedeli, Dario Livio Longo, Enzo Terreno, Fulvio Uggeri
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Abstract
The present invention relates to the use of non-equivalent mobile protons belonging to NMR distinguishable steroisomers of a CEST agent in a ratiometric based CEST imaging procedure and to Lanthanide (III) complex compounds displaying at least two NMR-distinguishable steroisomers in solution useful as concentration independent CEST responsive agents.
Claims2
A HPDO3A-Tetramer of formula
- a salt thereof or a chelated complex thereof with a paramagnetic metal ion.
A diagnostic composition comprising a (Yb3+)4HPDO3A-tetramer of formula
- together with suitable physiologically acceptable additives and/or carriers.
Dependencies are inferred from the claim text.