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US 10,328,160 B2Granted
Hollow silica nanospheres and methods of making same
AssigneeThe Regents of the University of California
InventorsWilliam C. Trogler, Sadik C. Esener, Davorka Messmer, Johan Ulrik Lind, Kristina K. P. Mitchell, Jian Yang
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Abstract
The disclosure provide hollow nanospheres and methods of making and using the same. The methods and compositions of the disclosure are useful for drug delivery and gene transfer.
Claims20
A method, comprising:
- (a) synthesizing a silica-shell precursor by hydrolyzing a silicon-containing compound in an acidic aqueous solution comprising about 0.01 M hydrochloric acid;
- (b) depositing the synthesized silica-shell precursor on a polyamino acid or polyamine functionalized template particle under a neutral pH condition in a range of 5.5 to 9.5 to give core-shell spheres, wherein the template particle comprises a non-magnetic material and a magnetic material;
- and
- (c) removing the non-magnetic material of the template particle by calcination or organic solvent to produce a hollow silica sphere, wherein the hollow silica sphere includes the magnetic material.
1 more element
A method, comprising:
- (a) synthesizing a silica-shell precursor by hydrolyzing a silicon-containing compound in an acidic solution comprising about 0.01 M of an acid selected from the group consisting of hydrochloric acid, sulfuric acid, nitric acid, or combinations thereof;
- (b) depositing the synthesized silica-shell precursor on a polyamino acid or polyamine functionalized template particle under a neutral pH condition in a range of 5.5 to 9.5 to give core-shell spheres, wherein the template particle comprises a non-magnetic material and a magnetic material;
- and
- (c) removing the non-magnetic material of the template particle by calcination or organic solvent to produce a hollow silica sphere, wherein the hollow silica sphere includes the magnetic material.
1 more element
Dependencies are inferred from the claim text.