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US 10,328,156 B2Granted
Compositions and methods for transport across the blood brain barrier
AssigneeOphidion Inc.
InventorAndreas Walz
Life of this patent
Estimating the term…
Abstract
Compositions and methods are provided including a transporter peptide derived from the loop2 domain of the neuronally-derived lynx1 protein which can be conjugated to an effector agent to form a transporter-effector complex for transport of the therapeutic effector agent to a target that is found across the blood brain barrier.
Claims16
A composition comprising the sequence of SEQ ID NO:10, or SEQ ID SEQ ID NO:
- 2 with SEQ ID NO:8 inserted between the third and fourth residues of SEQ ID NO:
- 2, or SEQ ID NO:
- 3 with SEQ ID NO:
- 8 inserted between the third and fourth residues of SEQ ID NO:
- 3, or SEQ ID NO:
- 5 with SEQ ID NO:
- 8 inserted between the third and fourth residues of SEQ ID NO:
- 5.
5 more elements
A composition comprising, a transporter peptide conjugate comprising:
- an effector agent;
- and a transporter peptide comprising:
- SEQ ID NO:10, or SEQ ID SEQ ID NO:
- 2 with SEQ ID NO:8 inserted between the third and fourth residues of SEQ ID NO:
- 2, or SEQ ID NO:
- 3 with SEQ ID NO:
- 8 inserted between the third and fourth residues of SEQ ID NO:
- 3, or SEQ ID NO:
- 5 with SEQ ID NO:
- 8 inserted between the third and fourth residues of SEQ ID NO:
- 5, the effector agent being conjugated to the transporter peptide.
8 more elements
Dependencies are inferred from the claim text.