Back to results
US 10,328,152 B2Granted
Method for stabilization and delivery of therapeutic molecules
AssigneeNayan Patel
InventorsNayan Patel, Chinh Tran
Life of this patent
Estimating the term…
Abstract
A method of treatment is disclosed, comprising administering a composition of Cyclodextrin and reduced, nanonized L-Glutathione to a patient in need of treatment, wherein the L-Glutathione molecule is non-acetylated, non-Esterified, and non-fatty acid attached.
Claims11
A topical composition comprising:
- an inclusion complex comprising:
- reduced glutathione, an additional antioxidant, and gamma cyclodextrin;
- wherein the reduced glutathione is non-esterified, non-acetylated, and non-fatty acid attached,
- wherein the additional antioxidant comprises at least one of the following:
- alpha-lipoic acid, ascorbic acid, uric acid, beta-carotene, alpha-tocopherol, dimethylethanolamine (DMAE), CoEnzyme Q10, vitamin E, carnosine, colloidal silver, catalase, superoxide dismutase, and peroxidase;
- wherein the molar ratio of reduced glutathione to gamma cyclodextrin is between about 4:1 and 13:1;
- wherein the complex is pH stabilized to a pH of between about 4.0 and about 7.8;
- and
- wherein ultrasonic waves nanonize the pH stabilized complex into nanoparticles having a particle size range between 2 to 200 nanometers in order to facilitate rapid absorption into the bloodstream.
6 more elements
A topical composition comprising:
- an inclusion complex comprising:
- reduced glutathione, an additional antioxidant, and gamma cyclodextrin;
- wherein the reduced glutathione is non-esterified, non-acetylated, and non-fatty acid attached;
- wherein the reduced glutathione is stabilized in a reaction mixture by bringing the reduced glutathione and the additional antioxidant in contact with the gamma cyclodextrin solubilized in a polar solution, wherein the molar ratio of reduced glutathione to gamma cyclodextrin is between about 4:1 and 13:1;
- wherein the additional antioxidant comprises at least one of the following:
- alpha-lipoic acid, ascorbic acid, uric acid, beta-carotene, alpha-tocopherol, dimethylethanolamine (DMAE), CoEnzyme Q10, vitamin E, carnosine, colloidal silver, catalase, superoxide dismutase, and peroxidase;
- wherein the reaction mixture is capped under vacuum after mixing at a pH range of 3.0 to 7.0;
- and
- wherein ultrasonic waves nanonize the pH stabilized complex into nanoparticles having a particle size range between 2 to 200 nanometers in order to facilitate rapid absorption into the bloodstream.
6 more elements
Dependencies are inferred from the claim text.