Vaccine for treatment or prevention of Burkholderia infection in a mammal
OwnerSiobhan McClean, Minu Shinoyinventors
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Abstract
An agent for use in a vaccine therapy to prevent or treat a Burkholderia infection in a mammal, wherein the agent is selected from a polypeptide of SEQUENCE ID NO:1, or a therapeutically effective variant thereof having at least 90% sequence identity with SEQUENCE ID NO: 1; a polypeptide of SEQUENCE ID NO:3, or a therapeutically effective variant thereof having at least 90% sequence identity with SEQUENCE ID NO: 3; and an immunogenic portion of the polypeptides of SEQUENCE ID NO:1 or SEQUENCE ID NO:3.
Claims4
A method of inducing an immune response to protect against or treat a Burkholderia infection in an individual, comprising a step of administering to the individual a therapeutically effective amount of an agent comprising a polypeptide of SEQUENCE ID NO:1.
A method of inducing an immune response in an individual with chronic granulomatous disease who does not have an infection caused by a Burkholderia strain to protect against a chronic lung infection by Burkholderia cepacia complex (Bcc) in said individual, comprising a step of administering to the individual a therapeutically effective amount of an agent selected from:
- a polypeptide of SEQUENCE ID NO:1;
- and a polypeptide of SEQUENCE ID NO:3.
A method of inducing an immune response to protect against melioidosis caused by a Burkholderia pseudomallei infection in an individual, comprising a step of administering to the individual a therapeutically effective amount of an agent consisting of an OMPW protein expressed by B. pseudomallei having an approximate molecular weight of 22kDA and an approximate PI of 7.8 to 9 and a GenInfo identifier of GI:134251653.
Dependencies are inferred from the claim text.