Compositions and methods of enhancing immune responses to Eimeria or limiting Eimeria infection
AssigneesBoard of Trustees of the University of Arkansas, The Texas A&M University System
InventorsJohn R. Barta, Luc Berghman, Srichaitanya Shivaramaiah, Olivia B. Faulkner, Lisa Bielke, Billy Hargis
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Abstract
Vaccine vectors and methods of using the vaccine vectors to enhance the immune response to an Apicomplexan parasite and reduce the morbidity or mortality associated with subsequent infection are provided herein. The vaccine vectors include a polynucleotide encoding a Rhomboid polypeptide and optionally include an immune-stimulatory polypeptide suitably expressed on the surface of the vaccine vector.
Claims19
A vaccine vector comprising a first polynucleotide sequence encoding an Apicomplexan Rhomboid polypeptide expressed on the surface of the vaccine vector, wherein the Rhomboid polypeptide consists of SEQ ID NO:
- 1, an immunogenic fragment of SEQ ID NO:
- 1 comprising at least 14 amino acids of SEQ ID NO:
- 1, or an immunogenic fragment of SEQ ID NO:
- 1 comprising amino acids 7-16 of SEQ ID NO:
- 1, and wherein the vaccine vector comprises a bacterial, yeast, viral or liposome-based vector.
Dependencies are inferred from the claim text.