Methods for stimulation of appetite and increase in weight by administration of asprosin
AssigneeBaylor College of Medicine
InventorsAtul Chopra, David D. Moore
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Abstract
Embodiments of the disclosure concern methods and compositions that relate to increasing or decreasing the weight (including, for example, by increasing or decreasing the adipose mass) in individuals in need thereof. Such methods and compositions, in particular embodiments, concern providing an effective amount of the hormone asprosin to increase adipose mass in an individual with insufficient adipose mass and providing an antibody or inhibitor of asprosin in an individual with obesity or diabetes, for example, to reduce adipose mass.
Claims6
A method of increasing the weight of an individual, comprising the step of providing an effective amount of an asprosin polypeptide comprising SEQ ID NO:1 to the individual, wherein the asprosin polypeptide does not comprise fibrillin.
A method of stimulating the appetite of an individual, comprising the step of providing an effective amount of recombinant asprosin polypeptide comprising SEQ ID NO:1 to the individual, wherein the recombinant asprosin polypeptide does not comprise fibrillin.
Dependencies are inferred from the claim text.