Peptides and compositions for treatment of joint damage
AssigneeNovartis AG
InventorsKristen Johnson, Jian Shi
Life of this patent
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Abstract
The present invention provides new protease-resistant polypeptides, as well as compositions and methods for treating, ameliorating or preventing conditions related to joint damage, including acute joint injury and arthritis.
Claims20
A method of inducing differentiation of mesenchymal stem cells into chondrocytes, the method comprising contacting mesenchymal stem cells in the joint of a subject suffering from arthritis or cartilage damage with an effective amount of a polypeptide comprising an amino acid sequence that has at least 95% amino acid sequence identity to an amino acid sequence selected from any one of SEQ ID NOs:
- 58-70, wherein the amino acid at position 423, as determined with reference to SEQ ID NO:
- 1, is deleted, to induce differentiation of the mesenchymal stem cells into chondrocytes, wherein said contacting is achieved by intra-articular delivery of the polypeptide to said subject.
A method of treating or ameliorating arthritis or cartilage damage in a joint of a subject in need thereof comprising administering to the subject at a site in need of treatment or by intra-articular delivery a therapeutically effective amount of a polypeptide comprising an amino acid sequence that has at least 95% amino acid sequence identity to an amino acid sequence selected from any one of SEQ ID NOs:
- 58-70, wherein the amino acid at position 423, as determined with reference to SEQ ID NO:
- 1, is deleted.
Dependencies are inferred from the claim text.