Treatments for neurological disorders
AssigneeGloriana Therapeutics, Inc.
InventorsAnthony Rossomando, Frank Porreca, Dinah Wen-Yee Sah
Life of this patent
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Abstract
Disclosed are methods of improving impaired proprioception, treating brachial plexus injuries, regenerating large and small nerve fibers, treating dorsal root nerve injuries, and improving sensory neural responses in a subject by administration of a neublastin polypeptide.
Claims19
A method of regenerating sensory nerve fibers, the method comprising administering to a human subject that has suffered an impairment or loss of sensory function and damage to or loss of sensory nerve fibers, an amount of a polypeptide effective to regenerate the sensory nerve fibers, the method resulting in the regeneration of the sensory nerve fibers and a persistent restoration of sensory function in the subject,
- the polypeptide consisting of amino acids 15-113 of SEQ ID NO:1, amino acids 15-113 of SEQ ID NO:2, amino acids 15-113 of SEQ ID NO:3, amino acids 15-113 of SEQ ID NO:
- 4, amino acids 15-113 of SEQ ID NO:8, or amino acids 15-113 of SEQ ID NO:
- 9,
- wherein the polypeptide, when dimerized, binds to a complex containing GFRα3 and RET, and
- wherein the polypeptide is administered to the subject within one month following the damage to or loss of nerve fibers.
Dependencies are inferred from the claim text.