Modulators of complement activity

A method of reducing hemolysis in a subject, the method comprising administration of a C5 inhibitor to the subject, wherein:

• the C5 inhibitor is a polypeptide comprising an amino acid sequence corresponding to amino acid residues 9-12 of SEQ ID NO:
• 192,
• the C5 inhibitor is administered at a frequency of from about every 12 hours to about every 72 hours, and
• wherein hemolysis in subject plasma is reduced by at least 90% during the course of administration.