Targeted adenoviruses and methods of making, isolating, and using
AssigneeRegents of the University of Minnesota
InventorMasato Yamamoto
Life of this patent
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Abstract
Described herein is an adenovirus comprising an AB-loop comprising a targeting motif and methods of making and using the adenovirus. The targeting motif of the adenovirus can selectively bind to a tumor cell. The targeting motif of the adenovirus can selectively bind to cell markers and/or cell surface antigens including, for example, CD 133.
Claims3
An adenovirus comprising an AB-loop comprising a targeting motif, wherein the targeting motif:
- selectively binds to a tumor cell;
- and
- comprises the amino acid sequence GERSGRW (SEQ ID NO:105).
An adenovirus comprising an AB-loop comprising a targeting motif, wherein the targeting motif:
- selectively binds to a tumor cell that expresses CD133;
- and
- comprises the amino acid sequence TYMLSRN (SEQ ID NO:106).
An adenovirus comprising an AB-loop comprising a targeting motif, wherein the targeting motif:
- selectively binds to a tumor cell;
- and
- comprises the amino acid sequence VRLLFYP (SEQ ID NO:107).
Dependencies are inferred from the claim text.