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US 10,328,099 B2Granted
Intradialytic use of sodium nitrite
AssigneeHope Medical Enterprises, Inc.
InventorCraig Sherman
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Abstract
Provided herein are methods for maintaining physiological levels of nitrite in a subject undergoing hemodialysis. Also provided herein are methods of administering pharmaceutically acceptable sodium nitrite to a subject undergoing hemodialysis.
Claims19
A method for maintaining physiological levels of nitrite in a subject undergoing hemodialysis;
- reducing the risk of myocardial infarction in a subject undergoing dialysis;
- reducing the risk of sudden cardiac death in a subject undergoing dialysis;
- reducing the risk of stroke in a subject undergoing dialysis;
- reducing the risk of cardiovascular disease that is characterized by tissue ischemia in a subject undergoing dialysis;
- reducing the risk of high blood pressure in a subject undergoing dialysis;
- reducing the risk of pulmonary hypertension in a subject undergoing dialysis;
- or reducing the risk of renal hypertension in a subject undergoing dialysis, comprising intradialytically contacting said subject's blood with a dialyzer membrane that is also in contact with a nitrite-spiked dialysate, wherein an aqueous solution comprising a therapeutically effective amount of sodium nitrite is added to an unspiked dialysate as the unspiked dialysate flows from a dialysis machine to a dialyzer membrane, wherein said unspiked dialysate comprises a mixture of water, an acid concentrate solution, and a bicarbonate concentrate solution, and wherein said nitrite-spiked dialysate has a pH greater than about 7.0.
4 more elements
Dependencies are inferred from the claim text.