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US 10,328,093 B2Granted
Anthracycline formulations
AssigneeCytRx Corporation
InventorsScott Geyer, Daniel Levitt, Carrie Nodgaard, Edward H. Trappler
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Abstract
The invention relates to reconstituted formulations comprising an anthracycline compound, ethanol, and water. The invention also relates to injectable compositions comprising the reconstituted formulation and Lactated Ringer's solution. Additionally, the invention relates to methods of using the formulations and compositions.
Claims39
A reconstituted formulation comprising:
- an anthracycline compound;
- a reconstitution liquid;
- and
- an agent selected from the group consisting of a bulking agent, a cryoprotectant, and a lyoprotectant,
- wherein said reconstituted formulation is prepared by reconstituting a lyophilized composition of the anthracycline compound in a reconstitution liquid comprising ethanol and water,
- wherein said reconstituted formulation is a solution, and
- wherein the anthracycline compound is DOXO-EMCH.
4 more elements
Dependencies are inferred from the claim text.