Methods and compositions for treatment of drug addiction
AssigneeThe Royal Institution for the Advancement of Learning/Mcgill University
InventorsDavid Stellwagen, Gil Moshe Lewitus
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Abstract
Methods of reducing AMPA/NMDA ratio in D1-type medium spiny neurons (MSN) and/or reducing development of behavioral sensitization or suppressing drug induced behavioral sensitization in a subject, optionally a subject that is afflicted with an addiction, the method comprising administering to the subject in need thereof an effective amount of a Toll-like receptor 4 (TLR4) agonist or a composition comprising said TLR4 agonist, preferably wherein the TLR4 agonist is a monophosphoryl lipid A (MPLA).
Claims21
A method of reducing AMPA/NMDA ratio in D1-type medium spiny neurons (MSN) and reducing development of behavioural sensitization or suppressing drug induced behavioural sensitization in a subject, optionally a subject that is afflicted with an addiction, comprising administering to the subject in need thereof an effective amount of a Toll-like receptor 4 (TLR4) agonist as active substance or a composition comprising said TLR4 agonist as active substance.
Dependencies are inferred from the claim text.