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US 10,328,083 B1Granted
Compositions and methods for treating stroke
AssigneeUniversity of South Florida
InventorsDavid Andrew Decker, Keith Pennypacker
Life of this patent
Estimating the term…
Abstract
Provided herein is a method of treating a subject believed to have suffered a stroke. This method comprises administering to the subject a therapeutically effective amount of a composition comprising conivaptan or an active derivative, stereoisomer, pro-drug, or pharmaceutically acceptable salt thereof.
Claims13
A method of treating a stroke or a suspected stroke in a subject in need thereof comprising:
- administering a first pharmaceutical formulation comprising a first amount of conivaptan or a pharmaceutically acceptable salt thereof to the subject in need thereof within 6 hours of stroke or estimated time of stroke, wherein the first amount is 0.35 mg/kg of bodyweight;
- and
- administering a second pharmaceutical formulation comprising a second amount of conivaptan or a pharmaceutically acceptable salt thereof to the subject in need thereof within 9 hours, 20 hours, 24 hours, 28 hours and 32 hours of stroke or estimated time of stroke, wherein the second amount is 0.07 mg/kg of bodyweight, wherein the administration of the first pharmaceutical formulation and the second pharmaceutical formulation is effective to reduce brain infarct size in the subject in need thereof.
Dependencies are inferred from the claim text.