[6R]-MTHF multiple bolus administration in 5-fluorouracil based chemotherapy

A method of treating a human diagnosed with a solid tumor, which method comprises:

• a) on Day 1, administering an IV bolus containing 10-1000 mg/m2 5-fluorouracil (5-FU) or a fluorinated pyrimidine base, followed, either simultaneously or after a period of 10 min-4 hours, by
• b) administering two or more IV boluses, interspaced by a period of 10-60 minutes, each containing 5-1000 mg/m2 [6R]-5,10-methylenetetrahydrofolate (6R-MTHF) on Day 1, followed by
• c) administering a continuous infusion of 5-FU or a fluorinated pyrimidine base over a period of 46 hours, or until the end of Day 2, followed by
• d) optionally administering one IV bolus containing 5-1000 mg/m2 6R-MTHF before the end of Day 1, followed by
• e) on Day 2, optionally administering one or more IV boluses each containing 5-1000 mg/m2 6R-MTHF,
• wherein step (b) is optionally repeated up to 4 times on Day 1 with an interval of 10 min-4 hours between each repetition, and wherein step (e) is optionally repeated up to 4 times on Day 2 with an interval of between 10 min-60 min between each bolus being administered, and wherein all steps (a)-(e) are optionally repeated every 2 weeks for up to eight (8) cycles.