Treatment of relapsed and/or refractory solid tumors and non-hodgkin's lymphomas

A method for the treatment of human merkel cell carcinoma, gastric neuroendocrine carcinoma, or small cell lung cancer comprising the administration to a patient in need thereof an effective amount of a compound having the structure of Formula (I), or a pharmaceutically acceptable salt thereof,

• wherein,
• W is N, C—H, or C—F;
• X is hydrogen, halogen, —CN, optionally substituted alkyl, optionally substituted alkynyl, optionally substituted carbocyclylalkynyl, optionally substituted aryl, or optionally substituted heteroaryl;
• Y is hydrogen, optionally substituted alkyl, optionally substituted cycloalkyl, or optionally substituted cycloalkylalkyl;
• Z is an optionally substituted group chosen from alkyl, carbocyclyl, C-attached heterocyclyl, N-attached heterocyclyl, heterocyclylalkyl, heterocyclylalkenyl, —O-heterocyclyl, —N(R)-heterocyclyl, —O-heterocyclylalkyl, —N(R)-heterocyclylalkyl, —N(R)(C1-C4alkylene)-NR2, —O(C1-C4alkylene)-NR2;
• and
• R is hydrogen or C1-C4alkyl.