Polymorphic forms of naltrexone
AssigneeAlkermes Pharma Ireland Limited
InventorsHarry G. Brittain, David A. Dickason, Joyce M. Hotz, Shawn L. Lyons, J. Michael Ramstack, Steven G. Wright
Life of this patent
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Abstract
This invention relates to the discovery of novel polymorphic forms of naltrexone, including solvates, hydrates, anhydrous and other crystalline forms and combinations thereof. These novel forms of naltrexone impart advantages in pharmaceutical formulations incorporating them, including sustained release, or long acting, formulations.
Claims4
A polymorphic form of naltrexone dimethylformamide solvate which is characterized by at least one of:
- (a) the X-ray powder diffraction pattern of FIG. 2A;
- (b) the differential scanning calorimetry thermogram of FIG. 14A;
- and
- (c) the IR-ATR spectrum of FIG. 26A.
A polymorphic form of naltrexone dimethylformamide solvate which is characterized by at least one of:
- (a) the X-ray powder diffraction pattern of FIG. 2B;
- (b) the differential scanning calorimetry thermogram of FIG. 14B;
- and
- (c) the IR-ATR spectrum of FIG. 26B.
Dependencies are inferred from the claim text.