Compositions of fatostatin based heterocyclic compounds and uses thereof
AssigneeFgh Biotech, Inc.
InventorsMotonari Uesugi, Joel Huff
Life of this patent
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Abstract
The present invention relates to compounds, pharmaceutical compositions and formulations that have a structure (I). The compounds comprise a heterocyclic ring where W, X, Y, and Z generally and independently are S, N or C with the proviso that at least 2 of these positions in the ring are other than carbon. A pyridine or a substituted pyridine A ring and a phenyl or a substituted phenyl B ring are covalently bonded to the heterocyclic ring. Further provided are methods for treating a metabolic disorder, cell proliferative disease, reducing body weight or increasing thermogenesis during weight loss with the compounds of structure as described or pharmaceutically acceptable salt or stereoisomer thereof or both.
Claims19
A compound selected from the group consisting of:
- where
- R is ethyl, n-propyl, isopropyl, —O—C1-3 alkyl, unsubstituted pyrrolidinyl, or unsubstituted morpholinyl;
- R1 is H, halogen, —OH, —O—C1-3 alkyl, —OC(O)R2, or —NR3R4;
- R2 is C1-C3 alkyl or aryl;
- R3 is H, C1-C3 alkyl, -alkylcyclopropane, cyclohexyl, benzyl, or —SO2—R5;
- R4 is H, C1-C3 alkyl, or —SO2—R5;
- and
- R5 is alkyl, cycloalkyl, aryl, or heteroaryl;
- or a pharmaceutically acceptable salt or a stereoisomer thereof or a combination thereof.
A compound selected from the group consisting of:
A compound according to the following formula:
- where Rz is
- Rz1 is —NO2, —NH2, —NHS(O)2CH3,
- NHS(O)2(isopropyl), —NH(isopropyl), or —NH(2-methylprop-1-yl);
- and
- Rz2 is —NH(isopropyl) or
- or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.