Treatment of Zika virus infections using alpha-glucosidase inhibitors
AssigneeThe Florida State University Research Foundation, Inc.
InventorsEric Holmes, Gary Ostrander
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Abstract
The present invention concerns the use of castanospermine or other alpha-glucosidase inhibitors for the treatment or prevention of Zika virus infections. Aspects of the invention include methods for treating or preventing Zika virus infection by administering an alpha-glucosidase inhibitor (e.g., an alpha-glucosidase I inhibitor) to a subject in need thereof; methods for inhibiting a Zika virus infection in a cell in vitro or in vivo; pharmaceutical compositions; packaged dosage formulations; and kits for treating or preventing Zika virus infection.
Claims3
A method for inhibiting a Zika virus infection in a cell, comprising contacting the infected cell in vitro with an alpha-glucosidase inhibitor, wherein the alpha-glucosidase inhibitor comprises castanospermine, a prodrug of castanospermine, or a pharmaceutically acceptable salt thereof.
Dependencies are inferred from the claim text.