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US 10,328,060 B2Granted
Certain protein kinase inhibitors
AssigneesShanghai Fochon Pharmaceutical Co., Ltd., Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Chongqing Fochon Pharmaceutical Co., Ltd.
InventorsXingdong Zhao, Jian Ding, Linghua Meng, Meiyu Geng, Tongshuang Li, Zuwen Zhou, Ling Chen, Qihong Liu, Xianlong Wang, Lijun Yang, Yue Rong, Rui Tan, Chuiliang Yu, Lihua Jiang, Yanxin Liu, Li Linghu, Jing Sun, Weibo Wang
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Abstract
Provided are certain PI3K inhibitors, pharmaceutical compositions thereof, and methods of use therefor.
Claims15
A compound of formula (I):
- or a pharmaceutically acceptable salt thereof, wherein:
- A-B is a 5-6 membered fused pyridone ring system, which is:
- W is
- R1 is selected from aryl, aryl-C1-4 alkyl, heteroaryl, and heteroaryl-C1-4 alkyl, wherein aryl and heteroaryl are each unsubstituted or substituted with at least one substituent independently selected from R6a;
- R2 is selected from hydrogen, C1-10 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, heterocyclyl, and heterocyclyl-C1-4 alkyl, wherein alkyl, cycloalkyl, and heterocyclyl are each unsubstituted or substituted with at least one substituent independently selected from R6a;
- R3 is selected from hydrogen, C1-10 alkyl, and C3-10 cycloalkyl, wherein alkyl and cycloalkyl are each unsubstituted or substituted with at least one substituent independently selected from R6a;
- R4 is selected from hydrogen, halogen, cyano, C1-10 alkyl, C3-10 cycloalkyl, and C3-10 cycloalkyl-C1-4 alkyl, wherein alkyl and cycloalkyl are each unsubstituted or substituted with at least one substituent independently selected from R6a;
- each R5 is independently selected from hydrogen, halogen, CF3, C1-10 alkyl, and C3-10 cycloalkyl, wherein alkyl and cycloalkyl are each unsubstituted or substituted with at least one substituent independently selected from R6a;
- each R6a is independently selected from C1-10 alkyl, C3-10 cycloalkyl, C3-10 cycloalkyl-C1-4 alkyl, OR8, NO2, halogen, SR8, NR7R8, and CN;
- each R7 and each R8 are independently selected from hydrogen and C1-10 alkyl;
- m is independently selected from 0, 1, and 2.
8 more elements
Dependencies are inferred from the claim text.