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AssigneesMayo Foundation for Medical Education and Research, Unity Biotechnology, Inc., Buck Institute for Research on Aging
InventorsDarren J. Baker, Marco Demaria, Albert Davalos, Bennett G. Childs, Jan M. A. van Deursen, James L. Kirkland, Tamar Tchkonia, Yi Zhu, Nathaniel David, Remi-Martin Laberge, Judith Campisi
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Foamy macrophages with senescence markers accumulate in the subendothelial space at the onset of atherosclerosis where they drive pathology by increasing expression of key atherogenic and inflammatory cytokines and chemokines. In advanced lesions, senescent cells promote features of plaque instability, including elastic fiber degradation and fibrous cap thinning, by heightening metalloprotease production. This invention provides methods and materials for treating arthritis by removing senescent cells in or around atherosclerotic plaques, thereby stabilizing the plaques, inhibiting rupture of the plaques and pathological sequelae that manifest as coronary artery disease.
A method of inhibiting progression of atherosclerosis in a subject, comprising treating the subject with a course of therapy using a pharmaceutical composition that contains a senolytic compound in an amount and in a formulation that is effective in eliminating p 16 positive senescent cells from a plurality of atherosclerotic plaques in the subject,
A method of removing senescent foam cell macrophages from the vasculature of a subject in need thereof, the method comprising:
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