Substituted pyrrolidines as mGluR5 antagonists

A compound of formula (I):

• or a pharmaceutically acceptable salt thereof,
• wherein:
• R1 is a 5- to 10-membered monocyclic or bicyclic heteroaryl that contains 1, 2 or 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, wherein the 5- to 10-membered monocyclic or bicyclic heteroaryl is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of alkyl, halogen, —OH, —CN, —NO2, —CF3, —O—CF3, —O-alkyl, —O-aryl, —S-alkyl, —S-aryl, —S(O)-alkyl, —S(O)-aryl, —S(O)2-alkyl, —S(O)2-aryl, —CH2-aryl, aryl, heteroaryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)-alkyl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)-aryl, —C(O)— heteroaryl, —C(O)O-alkyl, —C(O)O-cycloalkyl, —C(O)O-heterocycloalkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)NH-alkyl, —C(O)NH-cycloalkyl, —C(O)NH-heteroalkyl, —C(O)NH-aryl and —C(O)NH-heteroaryl, wherein the substituents may combine to form a 5-7 membered fused carbocyclyl or heterocyclyl;
• and
• R2 is —C(O)-alkyl, —C(O)-arylalkyl, —C(O)-aryl, —C(O)-heteroaryl, —S(O)2-aryl, —S(O)2-heteroaryl, —C(O)O-alkyl, —C(O)O-aryl, —C(O)O-arylalkyl or —C(O)—NH2, wherein the aryl or heteroaryl portion of the —C(O)-arylalkyl, —C(O)-aryl, —C(O)-heteroaryl, —S(O)2-aryl, —S(O)2-heteroaryl, —C(O)O-aryl and —C(O)O-arylalkyl is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of alkyl, halogen, —OH, —CN, —NO2, —CF3, —O—CF3, —O-alkyl, —O-aryl, —S-alkyl, —S-aryl, —S(O)-alkyl, —S(O)-aryl, —S(O)2-alkyl, —S(O)2-aryl, —CH2-aryl, heteroaryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)-alkyl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)O-alkyl, —C(O)O-cycloalkyl, —C(O)O-heterocycloalkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)NH— alkyl, —C(O)NH-cycloalkyl, —C(O)NH-heteroalkyl, —C(O)NH-aryl and —C(O)NH-heteroaryl, wherein the substituents may combine to form a 5-7 membered fused carbocyclyl or heterocyclyl;
• or
• R2 is a 5- to 10-membered monocyclic or bicyclic heteroaryl that contains 1, 2 or 3 heteroatoms selected from the group consisting of nitrogen, oxygen and sulfur, wherein the 5- to 10-membered monocyclic or bicyclic heteroaryl is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of alkyl, halogen, —OH, —CN, —NO2, —CF3, —O—CF3, —O-alkyl, —O-aryl, —S-alkyl, —S-aryl, —S(O)-alkyl, —S(O)-aryl, —S(O)2-alkyl, —S(O)2-aryl, —CH2-aryl, aryl, heteroaryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)-alkyl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)-aryl, —C(O)— heteroaryl, —C(O)O-alkyl, —C(O)O-cycloalkyl, —C(O)O-heterocycloalkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)NH-alkyl, —C(O)NH-cycloalkyl, —C(O)NH-heteroalkyl, —C(O)NH-aryl and —C(O)NH-heteroaryl, wherein the substituents may combine to form a 5-7 membered fused carbocyclyl or heterocyclyl;
• or
• R2 is a 5- to 10-membered monocyclic or bicyclic aryl, wherein the 5- to 10-membered monocyclic or bicyclic aryl is optionally substituted with 1, 2 or 3 substituents independently selected from the group consisting of alkyl, halogen, —OH, —CN, —NO2, —CF3, —O—CF3, —O-alkyl, —O-aryl, —S-alkyl, —S-aryl, —S(O)-alkyl, —S(O)-aryl, —S(O)2-alkyl, —S(O)2-aryl, —CH2-aryl, aryl, heteroaryl, —O—CH2-aryl, —N(CH3)2, cycloalkyl, heterocycloalkyl, —C(O)-alkyl, —C(O)-cycloalkyl, —C(O)-heterocycloalkyl, —C(O)-aryl, —C(O)-heteroaryl, —C(O)O-alkyl, —C(O)O-cycloalkyl, —C(O)O-heterocycloalkyl, —C(O)O-aryl, —C(O)O-heteroaryl, —C(O)NH— alkyl, —C(O)NH-cycloalkyl, —C(O)NH-heteroalkyl, —C(O)NH-aryl and —C(O)NH-heteroaryl, wherein the substituents may combine to form a 5-7 membered fused carbocyclyl or heterocyclyl.