Pharmaceutical suspensions containing drug particles, devices for their administration, and methods of their use

A method of administering a pharmaceutical composition to a subject, the method comprising:

• (a) inserting a drug delivery device having a reservoir containing the pharmaceutical composition into the mouth of the subject;
• (b) continuously or semicontinuously administering the pharmaceutical composition from the delivery device into the mouth of a patient at a rate between 0.001 mL/hour and 1.25 mL/hour, wherein said pharmaceutical composition comprises a suspension comprising (i) from about 20% to about 80% (w/w) solid excipients;
• (ii) from about 5% to 60% (w/w) drug particles, (iii) from 19% to 30% (w/w) of one or more water-immiscible compounds, (iv) from 2% to 25% (w/w) water, and (v) from 1% to 10% (w/w) surfactant, wherein the pharmaceutical composition is physically stable;
• and (c) removing said drug delivery device from the subject's mouth.

A method of treating a disease comprising administering a pharmaceutical composition comprising one or more drugs into the mouth of a patient via continuous or frequent intermittent administration for a period of at least 4 hours, said method comprising:

• (i) inserting a drug delivery device into the mouth of a patient;
• (ii) administering said pharmaceutical composition into the mouth of said patient via continuous or frequent intermittent administration at a rate between 0.001 mL/hour and 1.25 mL/hour for a period of at least 4 hours;
• and
• (iii) removing said drug delivery device from the mouth of said patient;
• wherein said pharmaceutical composition has a dynamic viscosity greater than 100 poise at 37° C. and comprises greater than about 35% (w/w) of said one or more drugs, and wherein the fluctuation index of one of said one or more drugs is less than or equal to 2.0 during said period.