Back to results
US 10,328,043 B1Granted
Composition and method for dual targeting in treatment of neuroendocrine tumors
AssigneeNanopharmaceuticals LLC
InventorsShaker Mousa, Mehdi Rajabi, Ozlem O. Karakus
Life of this patent
Estimating the term…
Abstract
Chemical compositions and methods of synthesis thereof. The compositions disclosed and described herein are directed toward thyroid hormone αvβ3 integrin receptor antagonists conjugated to targets of the norepinephrine transporter (NET) or the catecholamine transporter. The compositions have a dual targeting effect and increased targeting efficiency in the treatment and diagnostic imaging of neuroendocrine tumors.
Claims21
A composition comprising:
- a compound of
- a general formula:
- or a salt thereof;
- wherein n1≥0 and n2≥1.
1 more element
A method of treating a neuroendocrine tumor, comprising:
- administering to a subject in need thereof a therapeutically effective amount of a composition comprising a compound having a chemical formula:
- or a salt thereof;
- wherein n1≥0 and n2≥1.
A composition comprising:
- N-benzyl guanidine;
- and
- triazole tetrac;
- wherein the N-benzyl guanidine and the triazole tetrac are conjugated by polyethylene glycol.
1 more element
Dependencies are inferred from the claim text.