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US 10,328,038 B2Granted
Siderophore-polymer conjugates for increasing bacterial sensitivity to antibiotics
AssigneeWisconsin Alumni Research Foundation
InventorsMay Xiong, Max Purro
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Abstract
The present technology provides siderophore-polymer conjugates that enhance the sensitivity of bacteria to antibiotics, e.g., Pseudomonas, P. aeruginosa, Acinetobacter, and A. baumannii.Methods of preparing and using such conjugates to treat bacterial infections are disclosed.
Claims17
A method of treating a human having a bacterial infection comprising administering to the subject an effective amount of:
- a micelle comprising an antibiotic solubilized within the micelle, a conjugate, and optionally one or more pharmaceutically acceptable excipients;
- wherein the amount of antibiotic in the micelle is about 0.05 wt % to about 10 wt %;
- wherein the conjugate comprises a water-soluble polymer covalently attached to at least one siderophore-metal ion complex wherein water-soluble polymer is selected from polyethylene glycol (PEG) or a poloxamer, the siderophore is desferrioxamine B, and the metal is selected from Fe, Ga, Zn, Co, or Al;
- and
- wherein the bacterial infection is selected from the group consisting of a Pseudomonas, Acinetobacter, P. aeruginosa, and A. baumanni infection.
2 more elements
Dependencies are inferred from the claim text.