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US 10,328,035 B2Granted
Modified-release therapeutic systems for oral administration of menthol in the treatment of intestinal disorders
AssigneeMogon Pharmaceuticals Sagl
InventorMassimo Pedrani
Life of this patent
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Abstract
Disclosed are colon-specific delayed-release pharmaceutical compositions comprising: a) a matrix wherein micronized menthol with a particle-size distribution ranging between 100 nm and 1200 μm is dispersed b) a gastro-resistant or acid-resistant pH-independent coating with a lag time of matrix a).
Claims11
Monolithic colon-specific delayed release pharmaceutical compositions comprising:
- a) a core with a monolithic matrix comprising hydroxypropylmethylcellulose wherein menthol is dispersed in ground, co-ground, micronized form with a particle size ranging from 100 nm to 1200 μm,
- b) a gastro-resistant coating of the core a),
- wherein the menthol to hydroxypropylmethylcellulose weight ratio ranges from 1:5-4:1.
Dependencies are inferred from the claim text.