Polymeric adhesive matrix with salified carboxylic groups for transdermal use
AssigneeBouty S.P.A.
InventorsPaola Stefanelli, Alberto Scarsetto, Maurizio Di Grigoli, Pierbruno Romelli
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Abstract
Polymeric matrices for the controlled release of medicaments for the topical transdermal use comprising copolymers of acrylic and/or methacrylic acid or esters thereof having a Tg lower than 0° C., whose free carboxy groups are salified with compatible organic or inorganic bases. The matrices of the invention allow to prepare therapeutical systems for the controlled-release of active principles through the transdermal route, thus solving stability, solubility and/or bioavailability problems of the active ingredient within the matrix.
Claims7
Topical transdermal controlled release systems of medicaments consisting of:
- diclofenac as medicament;
- a polymeric matrix for said controlled release of said medicaments, said polymeric matrix consisting of copolymers of poly(2-ethyl-hexyl acrylate-co-acrylic acid-co-methyl acrylates) having a Tg lower than 0° C.,
- wherein the free carboxylic groups are salified with stoichiometric amounts of amino methyl-acrylate copolymers.
Topical transdermal controlled release systems of medicaments consisting of:
- diclofenac as medicament;
- 0.1 to 20% by weight of water, and
- a polymeric matrix for said controlled release of said medicaments, said polymeric matrix consisting of copolymers of poly(2-ethyl-hexyl acrylate-co-acrylic acid-co-methyl acrylates) having a Tg lower than 0° C.,
- wherein the free carboxylic groups are salified with stoichiometric amounts of amino methyl-acrylate copolymers.
Dependencies are inferred from the claim text.