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AssigneeIntegral Biosystems LLC
InventorsShikha P. Barman, Moli Liu, Koushik Barman, Kevin L. Ward, Brendan Hackett
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A nanostructured biocompatible wafer for drug delivery to a tissue. The wafer contains a tissue-reactive mucoadhesive polymer and a mesh formed of a plurality of polymer fibers. Also provided is a method for treating an ocular surface disease, disorder, or infection using the nanostructured biocompatible wafer. Additionally, an injectable sustained-release formulation for treating an ocular disorder is disclosed. The formulation includes a drug contained within a plurality of microparticles formed of a biodegradable polymer and are coated with a tissue-reactive compound. Further provided is a method for treating an ocular disorder by injecting the microparticulate sustained release formulation.
A nanostructured biocompatible water tor drug delivery to a tissue, the wafer comprising a tissue-reactive mucoadhesive polymer and a mesh formed of a plurality of polymer fibers, wherein the tissue-reactive mucoadhesive polymer is coated on the wafer or intercalated with the fibers, the wafer has a hydrated flexural modulus less than 25 MPa, the mesh has a pore size of 50 nm to 1000 nm, and the polymer fibers have a diameter of 100 nm to 1500 nm.
An injectable sustained-release formulation for treating an ocular disorder, the formulation comprising a drug contained within a plurality of microparticles each formed of a biodegradable polymer, and a dispersant compound coated on the microparticles, the microparticles having a size of 1 μm to 40 μm, wherein the microparticles contain 20% to 30% by weight of the biodegradable polymer and 5% to 20% by weight of the dispersant compound and the dispersant compound is selected from the group consisting of a silicone, lecithin, phosphatidylcholine, albumin, collagen, a polyethylene glycol (PEG)-fatty acid, a polyurethane, PEG-lecithin, poly(propylene oxide)-poly(ethylene oxide)-poly(propylene oxide), glycocholic acid, and cholic acid.
Dependencies are inferred from the claim text.