Pharmaceutical composition comprising amorphous lenalidomide and an antioxidant
AssigneeSynthon BV
InventorsMarta Vivancos Martinez, Lisardo Alvarez Fernandez, Jose Velada Calzada
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Abstract
The present invention relates to a pharmaceutical composition comprising amorphous lenalidomide, or a pharmaceutically acceptable salt thereof, with a synthetic antioxidant and one or more pharmaceutically acceptable excipients. The invention further relates to the process to manufacture such a compositions and the use of said composition as a medicament, particularly in the treatment of in the treatment of multiple myeloma and myelodyplastic syndromes.
Claims12
A pharmaceutical composition, comprising a solid dispersion of amorphous lenalidomide or a pharmaceutically acceptable salt thereof in a polymer;
- a monophenolic antioxidant compound;
- and one or more pharmaceutically acceptable excipients;
- wherein said polymer is PVP or co-PVP and wherein said antioxidant is present in an amount from 0.03 to 3% by total weight.
Dependencies are inferred from the claim text.