Amphiphilic polymer

A micelle comprising:

• an amphiphilic polymer comprising:
• a first block (A);
• and
• a second block (B) which is phase-separated from the first block (A) and includes a polymerization unit (B1) of an acrylic monomer or vinyl-based monomer of which a homopolymer has a solubility parameter of less than 10.0 (cal/cm3)1/2 and a polymerization unit (B2) of a polymerizable monomer having a functional group which is capable of forming a hydrogen bond,
• wherein the functional group is a nitro group, an imide group, an alkoxysilane group or a cyano group;
• wherein a weight ratio (B1:B2) of the polymerization unit (B1) of an acrylic monomer or vinyl-based monomer of which a homopolymer has a solubility parameter of less than 10.0 (cal/cm3)1/2 to the polymerization unit (B2) of a polymerizable monomer having a functional group which is capable of forming a hydrogen bond in the second block (B) is in a range of 1:9 to 9:1, and
• a drug encapsulated by the amphiphilic polymer, wherein the second block of the amphiphilic polymer is adjacent to the drug,
• wherein the drug includes an insoluble biologically active substance, and
• wherein the insoluble biologically active substance is one or more selected from the group consisting of genistein, daidzein, cucurbitacin, prangenidin and a derivative thereof.