Formulations and methods for vaginal delivery of antiprogestins

A method for treating a progesterone-dependent condition in a human female comprising administering to the vaginal mucosa of the female a mucoadhesive capsule comprising:

• 85 to 90 wt % pullulan;
• potassium chloride in an amount of 1.0% to 1.5% by weight;
• carrageenan in an amount of 0.1% to 0.4% by weight;
• one or more surfactants in an amount of 0.1 to 0.2% by weights;
• and water;
• and
• a fill formulation comprising the antiprogestin CDB-4124, and excipients comprising 30% to 60% w/w fatty acid esters, 30% to 60% w/w PEG 1000 and 0.1 to 5% w/w lecithin;
• wherein the progesterone-dependent condition is selected from the group consisting of endometriosis, adenomyosis, edometriomas of the ovary, dysmenorrhea, uterine fibroids, endometrial hyperproliferation, ovarian cancer, and cervical cancer.