Use of proline containing dipeptides
AssigneeDsm IP Assets B.V.
InventorsRemo Campiche, Dominik Imfeld, Alexandre Rio
Life of this patent
Estimating the term…
Abstract
Proline containing dipeptides are disclosed for up-regulating of genes involved in collagen fiber maturation and thus for revitalizing, strengthening and increasing the integrity of collagen fibers. These proline containing dipeptides are furthermore particularly suitable for improving the skin firmness, texture and elasticity as well as reducing the pore size and increasing skin moisturization.
Claims10
A method of treating skin to up-regulate genes involved in collagen fiber maturation, wherein the method comprises topically administering to an appropriate skin area of a person in need of treatment an effective amount of a cosmetic composition comprising at least one compound of formula (I) or a cosmetically acceptable salt thereof:
- wherein
- n represents 0, 1 or 2,
- R1 and R4 —independently of each other —are selected from the group consisting of H, C1-C6alkyl, amidino or tetra-C1-C6-alkylamidinium,
- R2 is H or C1-C6-alkyl, or R1 and R2 together with the residue to which they are bound form a 5- to 7-membered, saturated ring,
- R3 is selected from the group consisting of C1-C6alkyl, arC1-C6alkyl and heteroarylC1-C6alkyl, and
- R5 is H or, when n is 1, also NH2, or R5 and R1 together with the residue to which they are bound form a 5- to 7-membered, saturated ring.
Dependencies are inferred from the claim text.