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US 10,327,847 B2Granted
Method and system for patient-specific modeling of blood flow
AssigneeHeartFlow, Inc.
InventorCharles A. Taylor
Life of this patent
Estimating the term…
Abstract
Embodiments include a system for determining cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart, and create a three-dimensional model representing at least a portion of the patient's heart based on the patient-specific data. The at least one computer system may be further configured to create a physics-based model relating to a blood flow characteristic of the patient's heart and determine a fractional flow reserve within the patient's heart based on the three-dimensional model and the physics-based model.
Claims20
A non-transitory computer readable medium having stored thereon a computer program comprising instructions, which, when executed by a computer, cause the computer to perform a method for generating a measure or an indication of inhibition of blood flow, the method comprising:
- obtaining volume data or data of a series of images regarding an anatomy of an organ of a patient;
- generating, using the obtained volume data or the obtained data of a series of images, a three-dimensional patient-specific tissue model of the organ of the patient;
- subdividing the three-dimensional patient-specific tissue model into a first region and a second region;
- creating a first patient-specific blood flow model corresponding to the first region of the three-dimensional patient-specific tissue model of the organ;
- calculating, using the first patient-specific blood flow model corresponding to the first region of the three-dimensional patient-specific tissue model of the organ, a first blood flow value of perfusion into the first region of the three-dimensional patient-specific tissue model;
- creating a second patient-specific blood flow model corresponding to the second region of the three-dimensional patient-specific tissue model of the organ;
- calculating, using the second patient-specific blood flow model corresponding to the second region of the three-dimensional patient-specific tissue model of the organ, a second blood flow value of perfusion into the second region of the three-dimensional patient-specific tissue model;
- calculating a metric of inhibition of a blood flow in a blood vessel of the patient's organ, the metric comprising a ratio of the calculated first blood flow value of perfusion into the first region of the three-dimensional patient-specific tissue model to the calculated second blood flow value of perfusion into the second region of the three-dimensional patient-specific tissue model;
- and
- outputting, to an electronic storage medium or display, the calculated metric of inhibition of the blood flow in the blood vessel of the patient's organ.
7 more elements
A medical image processing method comprising:
- obtaining volume data or data of a series of images regarding an anatomy of an organ of a patient;
- generating, using the obtained volume data or the obtained data of a series of images, a three-dimensional patient-specific tissue model of the organ of the patient;
- subdividing the three-dimensional patient-specific tissue model into a first region and a second region;
- creating a first patient-specific blood flow model corresponding to the first region of the three-dimensional patient-specific tissue model of the organ;
- calculating, using the first patient-specific blood flow model corresponding to the first region of the three-dimensional patient-specific tissue model of the organ, a first blood flow value of perfusion into the first region of the three-dimensional patient-specific tissue model;
- creating a second patient-specific blood flow model corresponding to the second region of the three-dimensional patient-specific tissue model of the organ;
- calculating, using the second patient-specific blood flow model corresponding to the second region of the three-dimensional patient-specific tissue model of the organ, a second blood flow value of perfusion into the second region of the three-dimensional patient-specific tissue model;
- calculating a metric of inhibition of a blood flow in a blood vessel of the patient's organ, the metric comprising a ratio of the calculated first blood flow value of perfusion into the first region of the three-dimensional patient-specific tissue model to the calculated second blood flow value of perfusion into the second region of the three-dimensional patient-specific tissue model;
- and
- outputting, to an electronic storage medium or display, the calculated metric of inhibition of the blood flow in the blood vessel of the patient's organ.
7 more elements
A medical image processing apparatus configured to execute a method, the method comprising:
- obtaining volume data or data of a series of images regarding an anatomy of an organ of a patient;
- generating, using the obtained volume data or the obtained data of a series of images, a three-dimensional patient-specific tissue model of the organ of the patient;
- subdividing the three-dimensional patient-specific tissue model into a first region and a second region;
- creating a first patient-specific blood flow model corresponding to the first region of the three-dimensional patient-specific tissue model of the organ;
- calculating, using the patient-specific blood flow model corresponding to the first region of the three-dimensional patient-specific tissue model of the organ, a first blood flow value of perfusion into the first region of the three-dimensional patient-specific tissue model;
- creating a second patient-specific blood flow model corresponding to the second region of the three-dimensional patient-specific tissue model of the organ;
- calculating, using the second patient-specific blood flow model corresponding to the second region of the three-dimensional patient-specific tissue model of the organ, a second blood flow value of perfusion into the second region of the three-dimensional patient-specific tissue model;
- calculating a metric of inhibition of a blood flow in a blood vessel of the patient's organ, the metric comprising a ratio of the calculated first blood flow value of perfusion into the first region of the three-dimensional patient-specific tissue model to the calculated second blood flow value of perfusion into the second region of the three-dimensional patient-specific tissue model;
- and
- outputting, to an electronic storage medium or display, the calculated metric of inhibition of the blood flow in the blood vessel of the patient's organ.
7 more elements
Dependencies are inferred from the claim text.