System and method for using multiple sensor calibration methods

A method for improving glucose sensor accuracy by utilizing multiple calibration estimates, the method comprising the steps of:

• performing at least one in vivo update of surrounding glucose to acquire glucose values with the glucose sensor;
• applying multiple calibration estimates to the updated glucose values;
• calculating multiple updated calibration estimates using the updated glucose values;
• wherein each of the multiple calibration estimates is more accurate than the other of the multiple calibration estimates within one of a plurality of glucose concentration ranges;
• calculating an initial consensus glucose estimate value from sensor output using each updated calibration estimate;
• weighting the multiple updated calibration estimates based on the value of the initial consensus glucose estimate value such that the weights sum to unity, wherein the weights are smoothly shifted from zero to one among the multiple calibration estimates as a function of the initial consensus glucose estimate value in glucose concentration regions around boundaries of the plurality of glucose concentration ranges;
• determining a glucose level with the glucose sensor based on a weighted multiple calibration estimates;
• and
• displaying the determined glucose level on a display of a glucose blood measurement device.