Analyte sensors with a sensing surface having small sensing spots
AssigneeAbbott Diabetes Care Inc.
InventorsUdo Hoss, Phu Le, Yi Wang, Frank David Fujimoto, Suyue Qian, Lam Tran
Life of this patent
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Abstract
Embodiments of the present disclosure relate to analyte determining methods and devices (e.g., electrochemical analyte monitoring systems) that have a sensing surface that includes two or more sensing elements disposed laterally to each other, where the sensing surface is on a working electrode of in vivo and/or in vitro analyte sensors, e.g., continuous and/or automatic in vivo monitoring using analyte sensors and/or test strips. Also provided are systems and methods of using the, for example electrochemical, analyte sensors in analyte monitoring.
Claims37
A plurality of analyte sensors each comprising:
- a working electrode comprising a conductive material disposed on a substrate;
- a counter electrode;
- a sensing surface disposed on the conductive material of the working electrode, the sensing surface comprising two or more discontiguous sensing elements arranged thereon,
- wherein each discontiguous sensing element has an arcuate cross-sectional profile and semi-spherical shape, a diameter of 50 μm to 175 μm, a volume of 0.1 to 50 pico liters, and comprises an analyte-responsive enzyme;
- and
- a flux limiting membrane that covers the discontiguous sensing elements and is in contact with the working electrode between each discontiguous sensing element;
- and
- a sensor control unit comprising a processing circuit,
- wherein the sensor control unit comprising a processing circuit is configured to process factory-determined calibrated measurements that are input or stored in the sensor control unit, such that the plurality of analyte sensors are thereby factory calibrated, requiring no user calibration or recalibration.
A method comprising:
- monitoring a level of an analyte with at least a portion of at least one of a plurality of analyte sensors configured to be positioned into skin of a subject, wherein the plurality of analyte sensors each comprises:
- a working electrode comprising a conductive material disposed on a substrate;
- a counter electrode;
- a sensing surface disposed on the conductive material of the working electrode, the sensing surface comprising two or more discontiguous sensing elements arranged thereon,
- wherein each discontiguous sensing element has an arcuate cross-sectional profile and semi-spherical shape, a diameter of 50 μm to 175 μm, a volume of 0.1 to 50 pico liters, and comprises an analyte-responsive enzyme;
- and
- a flux limiting membrane that covers the discontiguous sensing elements and is in contact with the working electrode between each discontiguous sensing element;
- and
- a sensor control unit comprising a processing circuit, wherein the sensor control unit comprising a processing circuit is configured to process factory-determined calibrated measurements that are input or stored in the sensor control unit, such that the plurality of analyte sensors are thereby factory calibrated, requiring no user calibration or recalibration;
- and
- determining a level of an analyte over a period of time from signals generated by the analyte sensor.
Dependencies are inferred from the claim text.