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US 10,327,644 B2Granted
Bio-chips and nano-biochips
AssigneeInternational Business Machines Corporation
InventorEric V. Kline
Life of this patent
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Abstract
A biochip device, or a system of biochips, providing diagnostic testing, sensing and therapeutic functionality useful in diagnosis and treatment of a variety of physiological maladies.
Claims18
A system for monitoring one or more medical conditions in a subject, the system comprising:
- at least two biocompatible microchips, each microchip comprising:
- a housing including a biocompatible coating or covering,
- a first semiconductor substrate situated in said housing upon which is located one or more sensor devices for sensing conditions and providing measurements within said subject;
- a second semiconductor substrate situated in said housing including a programmed control unit and an associated memory block configured for controlling operations on said microchip in response to received external command or a sensed condition within said subject;
- a communications sub-system situated in said housing including one or more communications devices for transmitting signals to and receiving signals from a communications receiver device external to said subject;
- a plurality of storage vessels for storing therapeutic or diagnostic materials;
- and
- an output fluid connector partially housed in said housing in fluid communication with said one or more said storage vessels for outputting said therapeutic or diagnostic materials under control of said programmed control unit,
- wherein said at least two biocompatible microchips are interdependent, each biocompatible microchip adapted for implantation in a subject's body for sensing a mitosis rate in a local tissue, a first biocompatible microchip of said at least two biocompatible microchips having one or more measurement sensor devices affixed at a local area of a tissue being monitored in a subject and a second biocompatible microchip of said at least two biocompatible microchips in communication with the first biocompatible microchip and providing a stimulus signal for receipt by the first biocompatible microchip, said first biocompatible microchip sensing the stimulus signal and detecting a phase shift in wave components of the stimulus signal for use in detecting the local tissue mitosis rate.
6 more elements
Dependencies are inferred from the claim text.